Successful treatment of systemic sclerosis digital ulcers and pulmonary arterial hypertension with endothelin receptor antagonist bosentan.
نویسندگان
چکیده
SIR, We read with interest the recent reports describing the promising results of studies exploring the role of the dual endothelin receptor antagonist bosentan in pulmonary arterial hypertension (PAH) w1, 2x. We report the case of a patient with systemic sclerosis associated with PAH and ischaemic digital ulcerations who responded successfully to bosentan. A 50-yr-old male dentist presented in 1995 with severe Raynaud’s syndrome and acral systemic sclerosis. Over 2 yr, he had developed severe pruritus, worsening upper
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2003;47(Suppl.):1137. 6. Humbert M, Cabane J. Successful treatment of systemic sclerosis digital ulcers and pulmonary arterial hypertension with endothelin receptor antagonist bosentan. Rheumatology 2003;42:191–3. 7. Thompson AE, Shea B, Welch V, Fenlon D, Pope JE. Calciumchannel blockers for Raynaud phenomenon in systemic sclerosis. Arthritis Rheum 2001;44:1841–7. 8. Rodnan GP, Myerowitz RL, J...
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INTRODUCTION Pulmonary arterial hypertension is a fatal disease characterized by progressive remodeling of the pulmonary arteries and an increase in pulmonary vascular resistance. Up to 50% of patients with systemic sclerosis have pulmonary arterial hypertension, which significantly affects the prognosis. The endothelin receptor antagonist bosentan is used for the treatment of pulmonary arteria...
متن کاملDigital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist.
OBJECTIVE Recurrent digital ulcers are a manifestation of vascular disease in patients with systemic sclerosis (SSc; scleroderma) and lead to pain, impaired function, and tissue loss. We investigated whether treatment with the endothelin receptor antagonist, bosentan, decreased the development of new digital ulcers in patients with SSc. METHODS This was a randomized, prospective, placebo-cont...
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عنوان ژورنال:
- Rheumatology
دوره 42 1 شماره
صفحات -
تاریخ انتشار 2003